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| M | |
| .MAC | Macintosh macpaint files. |
| .MBX | Microsoft Outlook Express mailbox file. |
| .MCD | MechaniCad Drawing. |
| .MD | Compressed Archive file |
| .MDA | Microsoft Access Add-in / Microsoft Access 2 Workgroup. |
| .MDB | Microsoft Access Database / Microsoft Access Application. |
| .MDE | Microsoft Access Database File |
| .MDF | Menu definition file |
| .MDL | Digitrakker Music Module / Rational Rose / Quake model file |
| .MDM | Telix Modem Definition |
| .MDN | Microsoft Access Blank Database Template |
| .MDP | Microsoft Developer Studio Project |
| .MDT | Microsoft Access Add-in Data |
| .MDW | Microsoft Access Workgroup Information |
| .MDX | dBase IV Multiple Index |
| .MDZ | Microsoft Access Wizard Template |
| .MEB | WordPerfect Macro Editor bottom overflow file |
| .MED | WordPerfect Macro Editor delete save / OctaMed tracker module sound file. |
| .MEM | WordPerfect Macro Editor macro / Memory File of variables |
| .MID | Midi orchestra files that are used to play with midi sounds built within the sound card. |
| .MIM | MIME compressed file extracted and used with various compression utilities. |
| .MIX | Power C object file / Multiplayer Picture file (Microsoft Photodraw 2000 & Microsoft Picture It!) / Command & Conquer Movie/Sound file |
| .MKV | Short for Matroska, .MKV is similar to a .OGM file and is open source cross-platform movie file. |
| .MME | Compressed file extracted and used with various compression utilities. |
| .MNG | Multiple network graphics file. |
| .MOD | Winoldap files that support (with grabbers) data exchange between DOS apps and Windows apps. |
| .MOV | File used with Quick Time to display a move. |
| .MP1 | MPEG audio stream, layer I |
| .MP2 | MPEG audio stream, layer II |
| .MP3 | MPEG audio stream, layer III; High compressed audio files generally used to record audio tracks and store them in a decent sized file available for playback. See our MP3 page for additional information. |
| .MPP | Microsoft Project file. |
| .MPG | MPEG movie file. |
| .MRW | Digital camera RAW file format. |
| .MSC | Microsoft Common Console file. |
| .MSI | Microsoft Installer File. Used to setup and install a Microsoft program. |
| .MSN | Microsoft Network document / Decent mission file. |
| .MSP | Microsoft paint file format file or Microsoft Windows Installer patch |
| .MTF | Windows metafile. |
| .MTH | Derive Math file |
| .MTM | Sound file / MultiTracker music module |
| .MTV | Picture file |
| .MTW | Minitab data file |
| .MU | Quattro menu |
| .MUL | Ultima Online game |
| .MUP | Music publisher file |
| .MUS | Audio file |
| .MVB | Database file / Microsoft multimedia viewer file |
| .MVE | Interplay video file |
| .MVF | Movie stop frame file |
| .MWP | Lotus Wordpro 97 smartmaster file |
| .MXD | ArcInfo map file |
| .MXT | Microsoft C Datafile |
| .MYD | Make your point presentation file. |
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